Mitochondrial-derived peptide
See the units to draw for common MOTS-c doses across each reconstitution in the chart below, then use the calculator for your own vial, bacteriostatic water volume, and dose. MOTS-c is a research peptide that is not FDA-approved, with no established human dose.
Draw to
Draw to the 50 unit mark. That is 0.500 mL of solution.
Informational and educational only. Not medical advice. This tool performs math on values you enter and is not a substitute for your prescriber.
MOTS-c has no established human dose. Each row is the reconstitution math for a given dose, not a recommended or typical amount. For research use only; consult a licensed clinician.
| If your dose is | 1 mL (10 mg/mL) | 2 mL (5 mg/mL) | 3 mL (3.33 mg/mL) |
|---|---|---|---|
| 2.5 mg | 25 u | 50 u | 75 u |
| 5 mg | 50 u | 100 u | 150 u |
| 7.5 mg | 75 u | 150 u | 225 u |
| 10 mg | 100 u | 200 u | 300 u |
* Exceeds one 100-unit syringe (over 1 mL). Use a more concentrated mix (less water) or split into more than one draw.
Find your dose in the left column, then read across to the reconstitution you used (the amount of bacteriostatic water you added). The cell is the number of units to draw on a U-100 insulin syringe. The numbers are arithmetic for each reconstitution, not a recommended dose: MOTS-c has no established human dose.
Add your chosen volume of bacteriostatic water to the lyophilized vial, directing the stream gently against the glass wall, and swirl slowly (do not shake) until fully dissolved. The calculator above converts your vial size and water volume into the draw volume and units for your target dose.
It depends on how you reconstituted your vial. With a 10 mg vial in 2 mL of bacteriostatic water (5 mg/mL), a 2.5 mg dose is 0.5 mL, or 50 units. With the same vial in 1 mL (10 mg/mL), a 2.5 mg dose is 0.25 mL, or 25 units. Enter your own vial size and water volume above to get your number.
MOTS-c has no FDA-approved dosing guideline and no established clinical dose in humans. Community research protocols vary widely. This calculator performs math on the values you enter; it does not recommend any dose. Always consult a licensed clinician before using any research peptide.
No. MOTS-c is not approved by the FDA for any use. It is a research peptide studied preclinically for its role in metabolic regulation and insulin sensitivity. Human clinical data are very limited. It should not be used outside of a supervised research or clinical context.
Source: Mohtashami Z et al. MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases. Int J Mol Sci. 2022;23(19):11991. PMC9570330. · How we calculate