Mitochondrial-derived peptide

MOTS-c dosage calculator

Reconstitute MOTS-c, a research peptide that is not FDA-approved, and get the exact units to draw. Enter your vial strength, bacteriostatic water volume, and every-other-day dose for the precise mark on a U-100 insulin syringe.

Your reconstitution
Vial sizemg
Bacteriostatic water addedmL
Desired dosemg per injection
5 mg
0.5 mg steps · capped at your vial size

Draw to

100units on a U-100 insulin syringe

A 5 mg dose is 1.500 mL at this concentration.

At this concentration the dose exceeds the 100 unit (1 mL) capacity of a U-100 insulin syringe. Add more bacteriostatic water, or split it across two draws.

Concentration3.33mg per mL
Volume to draw1.500mL
Doses per vial2injections

Informational and educational only. Not medical advice. This tool performs math on values you enter and is not a substitute for your prescriber.

Common questions

How do I reconstitute MOTS-c?

Add your chosen volume of bacteriostatic water to the lyophilized vial, directing the stream gently against the glass wall, and swirl slowly (do not shake) until fully dissolved. The calculator above converts your vial size and water volume into the exact draw volume and units for your target dose.

How many units is a MOTS-c dose on a U-100 syringe?

It depends on how you reconstituted your vial. With a 10 mg vial in 2 mL of bacteriostatic water (5 mg/mL), a 2.5 mg dose is 0.5 mL, or 50 units. With the same vial in 1 mL (10 mg/mL), a 2.5 mg dose is 0.25 mL, or 25 units. Enter your own vial size and water volume above to get your exact number.

What is the MOTS-c dosage?

MOTS-c has no FDA-approved dosing guideline and no established clinical dose in humans. Community research protocols vary widely. This calculator performs math on the values you enter; it does not recommend any dose. Always consult a licensed clinician before using any research peptide.

Is MOTS-c FDA-approved?

No. MOTS-c is not approved by the FDA for any use. It is a research peptide studied preclinically for its role in metabolic regulation and insulin sensitivity. Human clinical data are very limited. It should not be used outside of a supervised research or clinical context.

Source: Mohtashami Z et al. MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases. Int J Mol Sci. 2022;23(19):11991. PMC9570330. · How we calculate